Stress & Sleep
the shape of your stress curve matters more than a single number.
A 4-point diurnal cortisol curve - morning, noon, afternoon, bedtime - plus DHEA-S, melatonin and pregnenolone. Maps exactly how your stress system is timed, whether it's flat (burnout), spiking at bedtime (3am wake-ups), or failing to rise in the morning.
- No insurance required
- HSA & FSA eligible
- CLIA-accredited labs
A single morning cortisol can miss burnout entirely - it's the shape of the curve that tells you what's happening.
Cortisol is pulsatile. Flat curves are a signature of HPA-axis downregulation ('adrenal fatigue' in the popular literature - more accurately, chronic stress adaptation). A spiking bedtime cortisol is the most common reason for 3am wake-ups and fragmented sleep.
The 57 biomarkers in this panel - and why each one.
Tap a marker to read the clinical note and the women-specific context.
Cortisol, Diurnal
A 4-point salivary cortisol curve maps the entire diurnal rhythm, revealing whether the HPA axis rises, peaks, and falls normally.
DHEA-S
The most abundant adrenal hormone and key precursor to sex steroids; declines steadily after age 30.
Melatonin
Pineal hormone that regulates circadian rhythm and sleep onset; suppressed by artificial light and stress-driven cortisol elevation.
Pregnenolone
The master steroid hormone precursor synthesized from cholesterol; converted to DHEA, progesterone, cortisol, and all sex steroids.
White Blood Cell Count
Total count of white blood cells; the front-line defense of the immune system.
Red Blood Cell Count
Total red blood cell count; used alongside hemoglobin and hematocrit to assess anemia.
Hemoglobin
The oxygen-carrying protein in red blood cells; the primary measure of anemia severity.
Hematocrit
The fraction of blood volume occupied by red blood cells.
MCV
Mean corpuscular volume — the average size of red blood cells; elevated in B12/folate deficiency, low in iron deficiency.
MCH
Mean corpuscular hemoglobin — the average amount of hemoglobin per red cell; low MCH is an early signal of iron depletion.
MCHC
Mean corpuscular hemoglobin concentration — classic for iron-deficiency anemia when low.
RDW
Red cell distribution width — measures variability in red cell size; elevated RDW reflects oxidative stress and mixed deficiencies.
Platelet Count
The circulating particles that initiate clotting; low counts increase bleeding risk, high counts can reflect inflammation or iron deficiency.
MPV
Mean platelet volume — larger platelets are more reactive; elevated MPV is associated with cardiovascular and thrombotic risk.
Absolute Neutrophils
Absolute count of neutrophils — the first responders to bacterial infection.
Absolute Band Neutrophils
Immature neutrophils (bands) — elevated counts (left shift) indicate acute bacterial infection or bone marrow stress.
Absolute Metamyelocytes
Immature granulocyte precursors; presence in blood indicates bone marrow stress or severe infection.
Absolute Myelocytes
Granulocyte precursors; circulating myelocytes indicate abnormal bone marrow release.
Absolute Promyelocytes
Very early granulocyte precursors; their presence in blood is abnormal and requires urgent evaluation.
Absolute Lymphocytes
Absolute count of lymphocytes — key mediators of adaptive immunity including T and B cells.
Absolute Monocytes
Absolute monocytes; these differentiate into macrophages and dendritic cells in tissue.
Absolute Eosinophils
Absolute eosinophils; respond to allergic reactions and parasitic infections.
Absolute Basophils
Absolute basophils — the rarest white cell, involved in allergic and inflammatory responses.
Absolute Blasts
Blast cells in peripheral blood; any presence is abnormal and requires immediate haematology referral.
Absolute Nucleated RBC
Nucleated red blood cells in peripheral blood; normally only present in foetal circulation and severe anaemia.
Neutrophils %
Percentage of neutrophils in the white cell differential; elevated in bacterial infection and stress.
Band Neutrophils %
Percentage of band (immature) neutrophils; elevated in acute bacterial infection.
Metamyelocytes %
Percentage of metamyelocytes; should be absent from normal peripheral blood.
Myelocytes %
Percentage of myelocytes; absent from normal blood.
Promyelocytes %
Percentage of promyelocytes; absent from normal blood.
Lymphocytes %
Percentage of lymphocytes in the white cell differential; reflects adaptive immunity.
Reactive Lymphocytes %
Atypical (reactive) lymphocytes; elevated in viral infections such as EBV and CMV.
Monocytes %
Percentage of monocytes; elevated in chronic infections and inflammatory conditions.
Eosinophils %
Percentage of eosinophils; elevated in allergic and parasitic conditions.
Basophils %
Percentage of basophils; mildly elevated counts can accompany allergic inflammation or thyroid disease.
Blasts %
Percentage of blasts; absent from normal blood. Any presence requires urgent evaluation.
Nucleated RBC %
Nucleated RBCs per 100 WBCs; should be absent in normal adults.
CBC Comment
Pathologist or automated comment on peripheral blood findings.
Glucose
Fasting serum glucose — the primary screen for diabetes and metabolic dysfunction.
Urea Nitrogen (BUN)
Blood urea nitrogen — a kidney filtration marker; elevated with dehydration or renal impairment.
Creatinine
Muscle waste product filtered by the kidneys; used to estimate GFR.
eGFR
Estimated glomerular filtration rate — the best single-number indicator of kidney function, calculated from creatinine using CKD-EPI.
BUN/Creatinine Ratio
The ratio of BUN to creatinine; helps distinguish pre-renal from intrinsic kidney causes of elevated BUN.
Sodium
Primary extracellular cation; regulates fluid balance and nerve/muscle function.
Potassium
Primary intracellular cation; critical for heart rhythm, muscle contraction, and nerve signalling.
Chloride
The main anion that balances sodium; used to evaluate acid-base and electrolyte status.
Carbon Dioxide (CO₂)
Serum bicarbonate reflecting the body's acid-base reserve; low values can indicate metabolic acidosis.
Calcium
Total serum calcium; critical for bone density, muscle contraction, and nerve signalling.
Protein, Total
Total serum protein (albumin + globulins); reflects overall nutritional status and liver and immune function.
Albumin
The most abundant serum protein; reflects liver synthetic function, nutrition, and systemic inflammation.
Globulin
Calculated globulin fraction (total protein minus albumin); includes immunoglobulins, clotting factors, and transport proteins.
Albumin/Globulin Ratio
The A/G ratio; a low ratio (reversed) can indicate autoimmune disease, liver disease, or malignancy.
Bilirubin, Total
The breakdown product of haemoglobin; elevated in liver disease, haemolysis, or bile duct obstruction.
Alkaline Phosphatase
Enzyme produced in liver and bone; elevated in cholestasis, bone disease, and pregnancy.
AST
Aspartate aminotransferase — liver and muscle enzyme; elevated with hepatocellular damage or intense exercise.
ALT
Alanine aminotransferase — the most specific liver enzyme; elevated in hepatitis, fatty liver, and medication toxicity.
hs-CRP
High-sensitivity C-reactive protein — the most sensitive blood measure of systemic low-grade inflammation.
Order this panel if any of these fit.
- 1You wake between 2 and 4am and can't fall back asleep
- 2You describe yourself as 'wired but tired' or burned out
- 3You crash at 3pm and need caffeine to function
- 4You're in perimenopause with insomnia as a new symptom
Three steps, no waiting room.
Choose your panel and complete a 2-minute intake. We schedule your lab visit or at-home phlebotomy appointment right after checkout.
Your collection supplies are handed off at your lab appointment or by your at-home phlebotomist. Take the four timed samples on a normal day and drop them at your lab partner - clear step-by-step instructions included.
Results in 7–10 days - a plain-language report with research-backed ranges for women and flags on anything that warrants follow-up. Share with your own clinician for interpretation.
Things people ask before ordering.
Cortisol should peak 30–45 minutes after waking and taper through the day. A single morning draw can look 'normal' even when the rest of the curve is broken. The pattern tells you the intervention.
Claims on this page are grounded in peer-reviewed research and society guidelines.
- [1]American Psychological Association: Stress in America - annual reports.APA
- [2]Karasek M et al. Melatonin, human aging, and age-related diseases.Exp Gerontol, 2004
- [3]Zhang B, Wing YK. Sex differences in insomnia: a meta-analysis.Sleep, 2006
- [4]Fries E et al. The cortisol awakening response (CAR): facts and future directions.Int J Psychophysiol, 2009
EllaDx panels are not a substitute for medical diagnosis. All results are reviewed by a licensed physician. Always consult a qualified clinician about changes to your care.